4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.
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4-hydroxyisoleucine an unusual amino acid as antidyslipidemic and antihyperglycemic agent.
Bioorg Med Chem Lett. 2006 Jan 15;16(2):293-6
Authors: Narender T, Puri A, Shweta , Khaliq T, Saxena R, Bhatia G, Chandra R
Trigonella foenum-graecum, commonly known as fenugreek, is an annual herbaceous plant. From the seeds of T. foenum-graecum an unusual amino acid, 4-hydroxyisoleucine 5, has been isolated, which significantly decreased the plasma triglyceride levels by 33% (P<0.002), total cholesterol (TC) by 22% (P<0.02), and free fatty acids by 14%, accompanied by an increase in HDL-C/TC ratio by 39% in the dyslipidemic hamster model.
PMID: 16246556 [PubMed - indexed for MEDLINE]
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