Agglomeration tendency in dry pharmaceutical granular systems.
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Agglomeration tendency in dry pharmaceutical granular systems.
Eur J Pharm Biopharm. 2006 May 10;
Authors: Lachiver ED, Abatzoglou N, Cartilier L, Simard JS
The agglomeration tendency of dry pharmaceutical mixtures containing various concentrations of Xylitab((R))100 (Xylitol), calcium carbonate precipitated (CCP) and magnesium stearate (MgSt) was evaluated statistically as a function of mixing time. A Ro-Tap tester was employed to mix the three pharmaceutical components, and the agglomerates formed were measured with respect to their weight and size. An experimental design was devised and applied to structure and then statistically analyze the results. Xylitab was found not to be influential in the formation of agglomerates, but aided in deagglomeration when mixed with other components. CCP and MgSt formed agglomerates over time and showed positive interactions favouring agglomeration. The agglomerates started to fracture when they reached a critical size, at which stage the particles’ attraction forces (cohesion forces) were weaker than both gravity and inertia. It has been shown and quantitatively demonstrated that the mixing time and ingredient concentrations of a three-component pharmaceutical mixture can affect agglomeration tendency.
PMID: 16797949 [PubMed - as supplied by publisher]
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