Effects of antenatal magnesium sulfate and corticosteroid therapy on sleep states of preterm infants.
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Effects of antenatal magnesium sulfate and corticosteroid therapy on sleep states of preterm infants.
Res Nurs Health. 2006 Jul 17;29(4):269-280
Authors: Black B, Holditch-Davis D, Schwartz T, Scher MS
This exploratory longitudinal study was designed to compare the neonatal illness severity, sleep-wake, and respiratory sleep behaviors of preterm infants whose mothers received prenatal corticosteroids and/or magnesium sulfate (MgSO(4)) with those of infants whose mothers did not receive these medications. The 134 infants were divided into four groups: those whose mothers received MgSO(4) only, those who received steroids only, those who received both MgSO(4) and steroids, and those who received neither. The groups did not differ on infant characteristics or illness severity. Infants exposed to MgSO(4) had more active sleep without rapid eye movement, indicating poorly organized active sleep. The MgSO(4)-only group had higher quiet sleep regularity scores and fewer state changes. These findings suggest that fetal exposure to MgSO(4) may subtly affect the central nervous system. (c) 2006 Wiley Periodicals, Inc. Res Nurs Health 29: 269-280, 2006.
PMID: 16847907 [PubMed - as supplied by publisher]
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