Endothelial dysfunction in MELAS improved by l-arginine supplementation.
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Endothelial dysfunction in MELAS improved by l-arginine supplementation.
Neurology. 2006 Jun 13;66(11):1766-9
Authors: Koga Y, Akita Y, Junko N, Yatsuga S, Povalko N, Fukiyama R, Ishii M, Matsuishi T
The authors evaluated endothelial function in patients with MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke) by flow-mediated vasodilation (FMD) and found a significant decrease vs controls. Two years of supplementation with oral l-arginine, a nitric oxide precursor, significantly improved endothelial function to control levels and was harmonized with the normalized plasma levels of l-arginine in patients. l-Arginine therapy improved endothelial dysfunction and showed promise in treating strokelike episodes in MELAS.
PMID: 16769961 [PubMed - in process]
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