Role of magnesium in hypertension.
 |
Related Articles |
Role of magnesium in hypertension.
Arch Biochem Biophys. 2006 May 24;
Authors: Sontia B, Touyz RM
Magnesium affects blood pressure by modulating vascular tone and reactivity. It acts as a calcium channel antagonist, it stimulates production of vasodilator prostacyclins and nitric oxide and it alters vascular responses to vasoactive agonists. Magnesium deficiency has been implicated in the pathogenesis of hypertension with epidemiological and experimental studies demonstrating an inverse correlation between blood pressure and serum magnesium levels. Magnesium also influences glucose and insulin homeostasis, and hypomagnesemia is associated with metabolic syndrome. Although most epidemiological and experimental studies support a role for low magnesium in the pathophysiology of hypertension, data from clinical studies have been less convincing. Furthermore, the therapeutic value of magnesium in the management of hypertension is unclear. The present review addresses the role of magnesium in the regulation of vascular function and blood pressure and discusses the implications of magnesium deficiency in experimental and clinical hypertension, in metabolic syndrome and in pre-eclampsia.
PMID: 16762312 [PubMed - as supplied by publisher]
Related posts:
- Magnesium supplementation for the management of essential hypertension in adults.
- Potassium magnesium supplementation for four weeks improves small distal artery compliance and reduces blood pressure in patients with essential hypertension.
- Long-term moderate magnesium-deficient diet shows relationships between blood pressure, inflammation and oxidant stress defense in aging rats.
- Combined calcium, magnesium and potassium supplementation for the management of primary hypertension in adults.
- Metabolic syndrome and hypertension: prevention and treatment.