Selected haematological and biochemical parameters of blood in rats after subchronic administration of vanadium and/or magnesium in drinking water.
 |
Related Articles |
Selected haematological and biochemical parameters of blood in rats after subchronic administration of vanadium and/or magnesium in drinking water.
Arch Environ Contam Toxicol. 2006 Aug;51(2):287-95
Authors: Scibior A, Zaporowska H, Ostrowski J
The purpose of these studies was to evaluate the effect of selected vanadium and magnesium doses on certain haematological and biochemical blood parameters in rats. Outbred 2-month-old, albino male Wistar rats received for a period of 6 weeks, as a sole drinking liquid, the following water solutions: group II, sodium metavanadate (SMV) at a concentration of 0.125 mg V/mL; group III, magnesium sulphate (MS) at a concentration of 0.06 mg Mg/mL; and group IV, SMV-MS solution at the same concentrations. The control group received at this time deionized water to drink. It was calculated that group II ingested with drinking water about 10.7 mg V/kg b. w./24 h, group III 6 mg Mg/kg b. w./24 h, and group IV about 9 mg V and 4.5 mg Mg/kg b. w./24 h. The exposure to vanadium alone (group II) led to a statistically significant decrease in body weight gain, food and fluid intakes. Moreover, in the same group of rats a statistically significant decrease in the RBC count, Hb concentration, MCV, and MCH values was demonstrated. Additionally, a statistically significant decrease in the plasma L-ascorbic acid concentration and a significant increase in MDA concentration in blood in this group were found. Instead, after the administration of magnesium alone (group III), a statistically significant decrease in the fluid intake and in the L-ascorbic acid concentration in plasma was noted. Furthermore, in the same group of rats a statistically significant increase in Hb level and in the plasma magnesium concentration was demonstrated. Two-way analysis of variance (ANOVA) did not reveal the interactions between V and Mg.
PMID: 16783625 [PubMed - in process]
Related posts:
- Comparison of nitrate levels in raw water and finished water from historical monitoring data on iowa municipal drinking water supplies.
- Effect of PVC and iron materials on Mn(II) deposition in drinking water distribution systems.
- Effects of oral administration of benzylamine on glucose tolerance and lipid metabolism in rats.
- Influence of selected Indian immunostimulant herbs against white spot syndrome virus (WSSV) infection in black tiger shrimp, Penaeus monodon with reference to haematological, biochemical and immunological changes.
- Hypoglycaemic effect of water extracts of Aegle marmelos fruits in streptozotocin diabetic rats.